Dynamic expression and essential functions of Hes7 in somite segmentation
نویسندگان
چکیده
منابع مشابه
Hes7 3′UTR is required for somite segmentation function
A set of genes in the posterior end of developing mouse embryos shows oscillatory expression, thereby regulating periodic somite segmentation. Although the mechanism for generating oscillation has extensively been clarified, what regulates the oscillation period is still unclear. We attempted to elongate the oscillation period by increasing the time to transcribe Hes7 in this research. We gener...
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Intronic delay is essential for oscillatory expression in the segmentation clock.
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متن کاملAccelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene.
Periodic somite segmentation is controlled by the cyclic gene Hes7, whose oscillatory expression depends upon negative feedback with a delayed timing. The mechanism that regulates the pace of segmentation remains to be determined, but mathematical modeling has predicted that negative feedback with shorter delays would give rise to dampened but more rapid oscillations. Here, we show that reducin...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2001
ISSN: 0890-9369
DOI: 10.1101/gad.930601